In vivo Models for Drug Discovery

This handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects.

In vivo Models for Drug Discovery

This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges. Key knowledge for drug researchers in industry as well as academia.

More Books:

In vivo Models for Drug Discovery
Language: en
Pages: 594
Authors: José Miguel Vela, Rafael Maldonado, Michel Hamon
Categories: Medical
Type: BOOK - Published: 2014-08-11 - Publisher: John Wiley & Sons

This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on
Animal Models of T Cell-Mediated Skin Diseases
Language: en
Pages: 291
Authors: T. Zollner, Harald Renz, Khusru Asadullah
Categories: Science
Type: BOOK - Published: 2007-01-19 - Publisher: Springer Science & Business Media

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a
Anticancer Drug Development Guide
Language: en
Pages: 451
Authors: Beverly A. Teicher, Paul A. Andrews
Categories: Medical
Type: BOOK - Published: 2004-02-01 - Publisher: Springer Science & Business Media

This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great
Drug Discovery Toxicology
Language: en
Pages: 584
Authors: Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, Brandon D. Jeffy
Categories: Medical
Type: BOOK - Published: 2016-04-18 - Publisher: John Wiley & Sons

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful
In Vivo Models of Inflammation
Language: en
Pages: 347
Authors: Lisa A. Marshall, Douglas W. Morgan
Categories: Medical
Type: BOOK - Published: 2013-11-11 - Publisher: Birkhäuser

The purpose of this volume in the series Progress in Inflammation Research is to pro vide the biomedical researcher with a description of the state of the art of the devel opment and use of animal models of diseases with components of inflammation. Par ticularly highlighted are those models which